Fluorescently labeled polarized Upcyte® hepatocytes. Credit: Prof. Yaakov Nahmias
A new technique for growing human hepatocytes in the laboratory has now been described by a team of researchers. This groundbreaking development could help advance a variety of liver-related research and applications, from studying drug toxicity to creating bio-artificial liver support for patients awaiting transplantations.
Human hepatocytes – that comprise 85% of the liver – are routinely used for study of hepatotoxicity, drug clearance and drug-drug interactions. They also have clinical applications in cell therapy to correct genetic defects, reverse cirrhosis, or support patients with a liver-assist device.
Regrettably, while the human liver can rapidly regenerate in vivo attempts to expand human hepatoc...
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