high cholesterol tagged posts

New Medication given every 1-3 months may Slash Stubborn High Cholesterol

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Organs in the body – transparent illustration
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While currently available PCSK9 inhibitor medications to lower cholesterol must be administered every few weeks by injection, a new, investigational PCSK9 inhibitor called recaticimab safely lowered bad cholesterol more than 50% when injected every 1-3 months, depending on dose.

A new PCSK9 inhibitor (recaticimab) injected every one to three months may work safely and provide more flexible dosing to lower cholesterol, according to late-breaking science presented today at the American Heart Association’s Scientific Sessions 2023. The meeting, Nov...

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Having High Cholesterol and Reduced Physical Stamina and being Overweight are Long COVID Sequelae in Young Adults

Having high cholesterol and reduced physical stamina and being overweight are long COVID sequelae in young adults
Test battery used in the Long COVID in Military Organizations study. The test battery was used to evaluate the long-term sequelae of COVID-19 in young adults. A variety of quantitative tests and standardized questionnaires were used to measure the effect on various organ systems and parameters in participants following COVID-19, asymptomatic SARS-CoV-2 infection, or in individuals who were non-exposed to SARS-CoV-2. Anti-N=anti-SARS-CoV-2 nucleocapsid. Anti-S=anti-SARS-CoV-2 spike. BDI-13=Beck Depression Inventory (13 items). CFQ-11=Chalder Fatigue Scale. eGFR=estimated glomerular filtration rate. FeNO=fractional exhaled nitric oxide. FSH=follicle stimulating hormone. HbA1c=glycated hemoglobin. IES-R=Impact of Event Scale-Revised. LH=luteinising hormone...
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Study links High Cholesterol, Cardiovascular Disease to Plastics

In a mouse study, a team led by a biomedical scientist found a phthalate — a chemical used to make plastics more durable — led to increased plasma cholesterol levels. Plastics, part of modern life, are useful but can pose a significant challenge to the environment and may also constitute a health concern. Indeed, exposure to plastic-associated chemicals, such as base chemical bisphenol A and phthalate plasticizers, can increase the risk of human cardiovascular disease. What underlying mechanisms cause this, however, remain elusive.

A team led by Changcheng Zhou, a biomedical scientist at the University of California, Riverside, now raises the hopes of solving the mystery...

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High Cholesterol Fuels Cancer by Fostering Resistance to a form of Cell Death

The proposed model to explain how cancer cells respond to 27HC treatment. Acute (left) treatment with 27HC disrupts lipid metabolism via interfering with SREBPs and LXR signaling, and this results in the inhibition of cell growth and migration. Cancer cells can adapt to the metabolic stress imposed by chronic treatment by 27HC (right). The cells that survive (27HC resistant cells) increase lipid uptake and accommodate the metabolic stress associated with this activity by upregulating the activity of processes that allow them to withstand lipid oxidative stress (ferroptosis); an activity which confers upon them enhanced tumor growth and metastatic capabilities. Numerical source data are reported in the Source Data File.

Chronically high cholesterol levels are known to be associated with...

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