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Compact ‘Gene Scissors’ enable Effective Genome Editing, may offer Future Treatment of High Cholesterol Gene Defect

Compact
In Gerold Schank’s lab, researchers from the University of Zurich have used protein engineering and an AI model to make the protein TnpB much more effective for genome editing. Credit: Christian Reichenbach

CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known “gene scissors” but is much smaller and thus easier to transport into cells.

Using protein engineering and AI algorithms, University of Zurich researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the future. The work has been published in Nature Methods.

CRISPR-Cas systems, which consist of protein and RNA components, we...

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