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    high fat diet tagged posts

    High-fat diet may cause changes in brain that lead to anxiety, depression

    October 26, 2015, Categories  Biology/Biotechnology, Health/Medical


    High-fat-diet-could-cause-brain-changes-that-lead-to-anxiety-and-depression-Mouse-data

    A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.

    Also, the beneficial effects of an antidepressant were blunted in mice fed a high-fat diet. “When treating depression, in general there is no predictor of treatment resistance,” said Dr. Bruno Guiard, senior author of the British Journal of Pharmacology study. “So if we consider metabolic disorders as a putative treatment resistance predictor, this should encourage psychiatrists to put in place a personalized treatment with antidepressant drugs that do not further destabilize metabolism.”

    On the other hand, taking mice off a high-fat diet completely reversed the animals’ metabolic impairments ...

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    Hot Chilli may Unlock a new Rx for

    August 19, 2015, Categories  Biology/Biotechnology, Health/Medical

    A high-fat diet may impair important receptors located in the stomach that signal fullness, researchers have discovered. They investigated the association between hot chilli pepper receptors (TRPV1) in the stomach and the feeling of fullness, in lab studies, suggesting that their work will inform further studies and the development of new therapies.

    “The stomach stretches when it is full, which activates nerves in the stomach to tell the body that it has had enough food. We found that this activation is regulated through hot chilli pepper or TRPV1 receptors,” says Associate Professor Amanda Page. “It is known from previous studies that capsaicin, found in hot chillies, reduces food intake in humans...

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    New VitB3 pathway found that Regulates Liver Metabolism

    August 9, 2015, Categories  Biology/Biotechnology, Chemistry/Nanotechnology, Health/Medical

    VitB3 3D model

    VitB3 3D model

    It will allow for novel drug development for obesity, diabetes type II and related metabolic diseases. A small molecule N1-methylnicotinamide prevents metabolic complications caused by a high-fat diet.

    “Our laboratory investigates the metabolic effects of nicotinamide adenine dinucleotide [NAD+], a metabolite derived from a form of vitamin B3 called nicotinamide,” explained assistant Prof Pavlos Pissios. NAD+ is central to intermediary metabolism, the intracellular process by which food is converted into cellular components in the body.

    “Like reservatrol, which is found in red wine, NAD+ boosts the effects of the protein sirtuin 1 [Sirt1], which is known to provide many health benefits,” said Pissios...

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