BTI Professor Daniel Klessig and lab members Research Associate Hyong Woo Choi and Postdoctoral scientist Murli Manohar.
Aspirin’s active form, salicylic acid, blocks a protein called HMGB1, which triggers inflammation in damaged tissues. The new findings may explain the disease-preventing effects of a low-dose aspirin regimen and offer hope that more effective aspirin-like drugs may be developed for a wide variety of diseases.
“We’ve identified what we believe is a key target of aspirin’s active form in the body, salicylic acid, which is responsible for some of the many therapeutic effects that aspirin has...
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