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Engineered Cartilage Template to Heal Broken Bones

Cartilage template formation via engineered extracellular matrix. Credit: Syam Nukavarapu/UConn Photo

Cartilage template formation via engineered extracellular matrix. Credit: Syam Nukavarapu/UConn Photo

A team of UConn Health researchers has designed a novel, hybrid hydrogel system to help address some of the challenges in repairing bone in the event of injury. There are over 200 bones in an adult human skeleton, ranging in size from a couple of millimeters in length to well over a foot. How these bones form and how they are repaired if injured varies, and has posed a challenge for many researchers in the field of regenerative medicine.

Two processes involved with human skeletal development help all the bones in our body form and grow. These processes are called intramembranous and endochondral ossification, IO and EO respectively...

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