hypoxia tagged posts

For the first time, researchers have shown that reduced oxygen intake, or “oxygen restriction,” is associated with longer lifespan in lab mice, highlighting its anti-aging potential. Robert Rogers of Massachusetts General Hospital in Boston, US, and colleagues present these findings in a study published May 23rd in the open access journal PLOS Biology.

Research efforts to extend healthy lifespan have identified a number of chemical compounds and other interventions that show promising effects in mammalian lab animals— for instance, the drug metformin or dietary restriction. Oxygen restriction has also been linked to longer lifespan in yeast, nematodes, and fruit flies. However, its effects in mammals have been unknown.

To explore the anti-aging...

Recent research has found that changes in the gut microbiota — the trillions of bacteria and other microbes that live in the intestines — can alter the brain and behavior. Now, a study led by scientists at UCLA could elucidate how and why that phenomenon occurs.

In the experiment, which was conducted with mice, researchers found that gut microbes can exacerbate the effects of cognitive impairment because of how they affect the hippocampus, the region of the brain that is critical for memory and learning...