Do more with one link - claim and personalize your FREE link today! Effortlessly schedule, video meet, message chat, network, share materials, e-sign, etc – all in one spot. Collaborate, Nurture connections, Improve client services, Expedite deal closures, and more. 💼 Join FREE!!

Recent Comments

    IBD tagged posts

    Green Tea and Iron, bad combination

    March 8, 2016, Categories  Biology/Biotechnology, Health/Medical

    egcggreen-tea

    Green tea has great antioxidants, but experiments in a lab mouse model of IBD suggest that consuming green tea along with dietary iron may actually lessen green tea’s benefits. “If you drink green tea after an iron-rich meal, the main compound in the tea will bind to the iron,” said Matam Vijay-Kumar, assistant professor of nutritional sciences, Penn State. “When that occurs, the green tea loses its potential as an antioxidant. In order to get the benefits of green tea, it may be best to not consume it with iron-rich foods.” Iron-rich foods include red meat and dark leafy greens, such as kale and spinach, iron supplements.

    Vijay-Kumar and colleagues found that EGCG – the main compound in green tea – potently inhibits myeloperoxidase, a pro-inflammatory enzyme released by white blood cells...

    Read More
    Single treatment with curli fibres ameliorates TNBS colitis. Colitis was induced in 6–8-week female Balb/c (n=6–7) mice by intrarectal instillation of 1% TNBS in 50% ethanol or 50% ethanol as a vehicle control. Day 1 post TNBS enema, mice were administered treatments as follows: 0.1 mg curli (oral), 0.4 mg curli (oral), 0.1 mg anti-TNFα (i.p.) or no treatment. (a) survival (n=6), (b) histopathological scores at day 6 post TNBS induction were plotted and (c) H&E images were taken. (d) Stool consistency scores were determined at day 3 post TNBS induction. It should be noted that larger areas of immune cell infiltration and lymphoid follicles in the submucosa was determined in the colonic tissue of mice treated with TNBS alone as compared with the groups that received curli treatment (*P<0.05; **P<0.01; ****P<0.0001). H&E, hematoxylin and eosin; i.p., intraperitoneal; TNBS, 2,4,6-trinitrobenzene sulphonic acid; TNF, tumour necrosis factor; Tx, treatment.

    Single treatment with curli fibres ameliorates TNBS colitis. Colitis was induced in 6–8-week female Balb/c (n=6–7) mice by intrarectal instillation of 1% TNBS in 50% ethanol or 50% ethanol as a vehicle control. Day 1 post TNBS enema, mice were administered treatments as follows: 0.1 mg curli (oral), 0.4 mg curli (oral), 0.1 mg anti-TNFα (i.p.) or no treatment. (a) survival (n=6), (b) histopathological scores at day 6 post TNBS induction were plotted and (c) H&E images were taken. (d) Stool consistency scores were determined at day 3 post TNBS induction...

    Read More

    Common Therapeutic Target for IBD Rx may Protect against Intestinal Inflammation by Inhibiting Pathogenic T-cells

    September 26, 2015, Categories  Biology/Biotechnology, Health/Medical

    Intracellular tumour necrosis factor receptor-2 (TNFR2) signalling. Binding of tumour necrosis factor (TNF) to TNFR2 results in activation and recruitment of intracellular adaptor proteins that induce signal transduction promoting cell proliferation and survival via phosphorylation of endothelial/epithelial nonreceptor tyrosine kinase (Etkp40), which in turn transactivates vascular endothelial growth factor receptor-2 (VEGFR2p1054–1059), leading to phosphatidylinositol 3-kinase (PI3K)-Akt/PKB pathway.

    Intracellular tumour necrosis factor receptor-2 (TNFR2) signalling. Binding of tumour necrosis factor (TNF) to TNFR2 results in activation and recruitment of intracellular adaptor proteins that induce signal transduction promoting cell proliferation and survival via phosphorylation of endothelial/epithelial nonreceptor tyrosine kinase (Etkp40), which in turn transactivates vascular endothelial growth factor receptor-2 (VEGFR2p1054–1059), leading to phosphatidylinositol 3-kinase (PI3K)-Akt/PKB pathway.

    This discovery could lead to new treatment options for the 65% of individuals with IBD who do not respond or become resistant to anti-TNF medications...

    Read More