ibuprofen tagged posts

Marked differences between males and females. The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis. The study in laboratory mice also shows marked differences between males and females.

Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs, widely used over the counter to treat pain and fever...

Researchers working on inhalable ibuprofen to treat cystic fibrosis

In cystic fibrosis, high dose ibuprofen helps slow decline of lung function, a disease caused by having two ‘bad’ copies of a gene that codes for a protein important in fluid secretion. Improved lung function is important, given that most people diagnosed die by their early 50s, usually due to chronic lung infections caused by their inability to move particles, including bacteria, up and out of the lungs. The downside is that ibuprofen doses that high, when taken routinely, can result in gastrointestinal (GI) bleeding and – when combined with the antibiotics that these patients often have to take for their recurring lung infections – acute kidney injury...