Lower BDNF levels observed in bipolar disorder patients may lead to reduced EGR3 levels. A dysfunctional pathway impairs several biological functions, including abnormal structural brain changes and cognitive and functional decline (known as neuroprogression). Disrupted neural circuits may explain the impaired neuroplasticity and resilience, increasing vulnerability to stress and mood episodes, all well-known characteristics of BD.
A new article reveals a novel potential drug target for bipolar disorder and offers new insights into the underlying biology of this lifelong and devastating mental illness. Bipolar Disorder (BD) is a multifactorial brain disorder in which patients experience radical shifts in mood and undergo periods of depression followed by periods of mania...
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