Do more with one link - claim and personalize your FREE link today! Effortlessly schedule, video meet, message chat, network, share materials, e-sign, etc – all in one spot. Collaborate, Nurture connections, Improve client services, Expedite deal closures, and more. 💼 Join FREE!!

Recent Comments

    IFN-gamma tagged posts

    Disabling erbB Pathway + IFN-γ Therapy Eradicates a Breast Cancer type in mice

    October 7, 2015, Categories  Biology/Biotechnology, Health/Medical

    Highlights •IFN-γ and 4D5 act directly on erbB2-positive breast cancer cells •IFN-γ, but not IFN-α or β, cooperates with 4D5 directly on erbB2+ breast cancer cells •IFN-γ and 4D5 alters KLF4 levels and degrades Snail by the GSK3-β/proteasome pathway •Sequential combination treatment with mAb and IFN-γ sensitizes for tumor eradication

    Highlights •IFN-γ and 4D5 act directly on erbB2-positive breast cancer cells •IFN-γ, but not IFN-α or β, cooperates with 4D5 directly on erbB2+ breast cancer cells •IFN-γ and 4D5 alters KLF4 levels and degrades Snail by the GSK3-β/proteasome pathway •Sequential combination treatment with mAb and IFN-γ sensitizes for tumor eradication. Credit: http://dx.doi.org/10.1016/j.celrep.2015.08.044

    This therapy, when translated for use in people humans, would be beneficial in reducing toxicity because the amount of antibody could be decreased by 2/3 and the amount of chemotherapy by at least 1/2, they say. This in turn, “reduces the cost of treatment so that individuals previously not able to afford targeted therapy will be able to do so.

    “This line of research is important to future ...

    Read More