IgG tagged posts

Scientists Identify Genes linked to High Production of Key Antibody

A rendering of a nanovial, a microscopic bowl-shaped container that the scientists used to capture individual cells and their secretions. The dark, donut-shaped object to the right is a cell; the blue-and-yellow objects to the left are secreted immunoglobulin G antibodies. (Image courtesy: Rene Chang/University of Washington)

A collaboration led by UCLA and the Seattle Children’s Research Institute has yielded new knowledge about the genes responsible for the production and release of immunoglobulin G, the most common type of antibody in the human body.

The finding has the potential to advance manufacturing of antibody-based therapies for diseases such as cancer and arthritis, as well as the development of medical treatments that rely on the production of antibodies.

Antibodies a...

Read More

Can you spread Covid-19 if you get the Vaccine?

We know that the vaccines now available across the world will protect their recipients from getting sick with Covid-19. But while each vaccine authorized for public use can prevent well over 50% of cases (in Pfizer-BioNTech and Moderna‘s case, more than 90%), what we don’t know is whether they’ll also curb transmission of the SARS-CoV-2 virus.

That question is answerable, though—and understanding vaccines’ effect on transmission will help determine when things can go back to whatever our new normal looks like.

The reason we don’t know if the vaccine can prevent transmission is twofold. One reason is practical...

Read More

Why Protecting the Brain Against Infection Takes Guts

Confocal micrograph showing the superior saggital sinus in the mouse. Immune cells are shown in green lining this tube, and blood vessels in red
Confocal micrograph showing the superior saggital sinus in the mouse. Immune cells are shown in green lining this tube, and blood vessels in red
Credit: Zach Fitzpatrick

The brain is uniquely protected against invading bacteria and viruses, but its defence mechanism has long remained a mystery. Now, a study in mice, confirmed in human samples, has shown that the brain has a surprising ally in its protection: the gut.

The brain is arguably the most important organ in the body, as it controls most other body systems and enables reasoning, intelligence, and emotion. Humans have evolved a variety of protective measures to prevent physical damage to the brain: it sits in a solid, bony case — the skull — and is wrapped in three layers of watertight tissue known as the meninges.

What has...

Read More