immune cells tagged posts

Drug Triggers Immune Cells to Attack Prostate Cancer

A drug compound stimulates immune cells to attack prostate tumors, according to new research from Washington University School of Medicine in St. Louis. Shown is a human prostate cancer organoid, a small 3D structure that serves as a model of prostate tumors. When the organoid is grown with prostate cancer patients’ immune cells, which have been treated with the drug, the immune cells attack the cancer. Red shows dead cells. Blue shows DNA.

A single drug compound simultaneously attacks hard-to-treat prostate cancer on several fronts, according to a new study in mice and human cells...

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Nanosecond Pulsed Electric fields activate Immune cells

figure3
Analysis of extracellular DNA by agarose gel electrophoresis. (A) Schematic representation of MNase treatment for liberation of extruded DNA from cells. MNase digests extracellular chromosomal DNA at its linker regions among nucleosomes, leading to the liberation of extracellular chromosomal DNA from their originating cells. Liberated DNA was separated from cells by brief centrifugation and in turn subjected to either DNA purification followed by agarose gel electrophoresis (B) or direct fluorometric measurement with a SYTOX Green dye (Fig. 4). (B) Analysis of MNase-treated extracellular DNA by agarose gel electrophoresis. Differentiated (D) and undifferentiated cells (U) were exposed to the indicated shot numbers of 20 kV/cm nsPEFs...
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Secret Tunnels Discovered between the Skull and the Brain

Newly discovered channels in the skull may provide a shortcut for immune cells going to damaged tissue. Credit: Nahrendorf Lab

Newly discovered channels in the skull may provide a shortcut for immune cells going to damaged tissue. Credit: Nahrendorf Lab

Study suggests immune cells rush through channels to get to injured tissue quickly. Bone marrow, the spongy tissue inside most of our bones, produces red blood cells as well as immune cells that help fight off infections and heal injuries. According to a new study of mice and humans, tiny tunnels run from skull bone marrow to the lining of the brain and may provide a direct route for immune cells responding to injuries caused by stroke and other brain disorders. The study was funded in part by the National Institutes of Health and published in Nature Neuroscience.

“We always thought that immune cells from our arms and legs traveled via blood to damaged brain tissue...

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Discovery reveals how Obesity causes disease – and 2 ways to stop it

Norbert Leitinger, Ph.D. (left), and Vlad Serbulea, Ph.D., of the University of Virginia School of Medicine, have determined why obesity causes harmful inflammation that can lead to diabetes, clogged arteries and other health problems. Doctors may be able to use this knowledge to battle these chronic diseases and others driven by damaging inflammation.
Credit: Dan Addison, University of Virginia Communications

Finding points to new approaches to battling diabetes, other chronic conditions. New research from the University of Virginia School of Medicine explains why obesity causes harmful inflammation that can lead to diabetes, clogged arteries and other health problems. Doctors may be able to use this knowledge to battle these chronic diseases and others driven by damaging inflammation...

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