immune checkpoint blockade tagged posts

Common Immune Response is found to be Protective Across Many Diseases

Common immune response protective across many diseases
Overview of study design, analytic methods, and dataset multi-omics. (A) Cartoon describing the collected single-cell and bulk multi-omic datasets with paired clinical data from infection, autoimmunity, and cancer contexts. (B) Cartoon depicting experimental and analytic strategies for single-cell and bulk data with a focus on NKG2A/C-expressing cell types. (C) Cartoon demonstrating NKG2A+ and NKG2C+ bias assignment at single-cell and bulk levels. (D) Cartoon displaying the different clinical and biological -omics to be compared between NKG2A+ and patients with an NKG2C+ bias. Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.113872

Combined, infection, autoimmunity and cancer account for 4 out of every 10 deaths worldwide, and represent major global health challenges...

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Dietary Fiber improves outcomes for Melanoma Patients on Immunotherapy

Examples of dietary fiber, photo provided by NIH

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration that includes the Oregon State University College of Pharmacy.

Published today in Science, the study led by the University of Texas and the National Institutes of Health is a promising development in the fight against multiple types of cancer including melanoma, the most deadly form of skin cancer, the researchers said.

Nationwide, melanoma is the fifth-most common cancer...

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Researchers discover the Microbiome’s role in attacking Cancerous Tumors

The Microbiome's Role in Attacking Cancerous Tumors | Technology ...
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapyScience, 2020; eabc3421 DOI

Researchers with the Snyder Institute for Chronic Diseases at the Cumming School of Medicine (CSM) have discovered which gut bacteria help our immune system battle cancerous tumours and how they do it. The discovery may provide a new understanding of why immunotherapy, a treatment for cancer that helps amplify the body’s immune response, works in some cases, but not others. The findings, published in Science, show combining immunotherapy with specific microbial therapy boosts the ability of the immune system to recognize and attack cancer cells in some melanoma, bladder and colorectal cancers.

Dr...

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