immune system tagged posts

Sex Hormones Modulate the Immune System to Influence Disease Risk Differently, study finds

Researchers have uncovered how hormones profoundly affect our immune systems, explaining why men and women are affected by diseases differently.

Scientists from the Karolinska Institutet in Sweden and Imperial College London have shown for the first time which aspects of our immune systems are regulated by sex hormones, and the impacts this has on disease risk and health outcomes in males and females.

It is well established that diseases can affect men and women differently, due to subtle differences in our immune systems. For example, the immune condition systemic lupus erythematosus (SLE) is nine-times more likely to affect women, or with COVID-19, males are known to have a greater risk of acute first-time infections, while females have a greater risk of long-COVID.

But it ...

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Some benefits of Exercise stem from the Immune System, suggests new study

Two images comparing inflammation in hindleg muscles of mice
The hind leg muscles of mice lacking Treg cells (right) showed prominent signs of inflammation after regular exercise, compared with those of mice with intact Tregs (left). The research showed that this uncontrolled inflammation negatively impacted muscle metabolism and function. Images: Kent Langston/Mathis Lab, HMS

The connection between exercise and inflammation has captivated the imagination of researchers ever since an early 20th-century study showed a spike of white cells in the blood of Boston marathon runners following the race.

Now, a new Harvard Medical School study published in Science Immunology may offer a molecular explanation behind this century-old observation.

The study, in mice, suggests that the beneficial effects of exercise may be driven, at least partly, by ...

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How the Immune System can Alter our Behavior

A woman looking at tomatoes, nuts, shrimp, and fish
(© stock.adobe.com)

Simply the smell of seafood can make those with an allergy to it violently ill — and therefore more likely to avoid it. The same avoidance behavior is exhibited by people who develop food poisoning after eating a certain meal.

Scientists have long known that the immune system played a key role in our reactions to allergens and pathogens in the environment, but it was unclear whether it played any role in prompting these types of behaviors towards allergic triggers.

According to Yale-led research published July 12 in the journal Nature, it turns out that the immune system plays a crucial role in changing our behaviors.

“We find immune recognition controls behavior, specifically defensive behaviors against toxins that are communicated first through antibodie...

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Nanomaterial influences Gut Microbiome and Immune system Interactions

Decorative image
A new study by researchers at Karolinska Institutet shows that the aryl hydrocarbon receptor (AhR) in intestinal epithelial cells senses the nanomaterial graphen oxide and activates specific immune cells known as innate lymphoid cells. Illustration by Getty Images.

The nanomaterial graphene oxide — which is used in everything from electronics to sensors for biomolecules — can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden. The findings are reported in the journal Nature Nanotechnology.

“This shows that we must factor the gut microbiome into our understanding of how nanomaterials affect the immune system,” says the paper’s corresponding author Bengt Fadeel, professor at the Institute o...

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