immunity tagged posts

Dietary restriction fuels T-cells with ketones, boosting their cancer-fighting stamina

T cell
Credit: Pixabay/CC0 Public Domain

Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators. The findings lay the groundwork for developing dietary strategies to boost the effects of a powerful class of cancer immunotherapies.

“Growing evidence suggests dietary restriction has anti-cancer effects but the ‘why and how’ are not well understood. Our new study reveals one way this relationship may work: by providing T cells, the soldiers of the immune system, with the right mix of nutrients to more effectively fight cancer,” said Russell Jones, Ph.D., chair of VAI’s Department of Metabolism and Nutritional Programming and corresponding author of the study.

“Additional research is need...

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Gut reaction: How Immunity ramps up against Incoming Threats

Image result for VIP directly regulates IL-22 production by ILC3s.
ILC2 and ILC3 activities oscillate during the active and resting phase at steady state in wild-type mice.

A new study has revealed how the gut’s protective mechanisms ramp up significantly with food intake, and at times of the day when mealtimes are anticipated based on regular eating habits.

Researchers from the Walter and Eliza Hall Institute found, in laboratory models, that eating sets off a hormonal ‘chain reaction’ in the gut.

Eating causes a hormone called VIP to kickstart the activity of immune cells in response to potentially incoming pathogens or ‘bad’ bacteria. The researchers also found that immunity increased at anticipated mealtimes indicating that maintaining regular eating patterns could be more important than previously thought.

With the rise in conditions a...

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A Lifetime of Regular Exercise Slows down Aging, study finds

Researchers at the University of Birmingham and King's College London have found that staying active keeps the body young and healthy. Credit: University of Birmingham

Researchers at the University of Birmingham and King’s College London have found that staying active keeps the body young and healthy. Credit: University of Birmingham

A group of older people who have exercised all of their lives, were compared to a group of similarly aged adults and younger adults who do not exercise regularly. The results showed that those who have exercised regularly have defied the aging process, having the immunity, muscle mass, and cholesterol levels of a young person. Researchers at the University of Birmingham and King’s College London recruited 125 amateur cyclists aged 55 to 79, 84 of which were male and 41 were female. The men had to be able to cycle 100 km in under 6.5 hours, while the women had to be able to cycle 60 km in 5.5 hours...

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