immunosuppression tagged posts

Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression. Nanoparticle-driven spleen remodeling allowed transplanted mouse, rat, and human islets to restore normal blood sugar in diabetic rodents and cynomolgus macaques.

In type 1 diabetes, the immune system destroys native beta cells, the insulin-producing cells housed within pancreatic clusters called islets of Langerhans...

Staphylococcus aureus bacteria (colored green) interacting with a human immune cell. This study shows that in conditions like toxic shock syndrome, toxins from such bacteria can trigger one type of immune cells (MAIT cells) to turn against the host. Credit: NIAID; CC-BY

A subpopulation of immune cells that normally fend off pathogens can turn against the host during certain infections, a new study publishing on June 20 in the open access journal PLOS Biology reveals. The researchers led by Dr...