Brain scans are from glioblastoma trial from manuscript. Credit: Clinical Cancer Research/American Association for Cancer Research
Dendritic cell vaccine supports further study in larger trials. A phase 1 study of 11 patients with glioblastoma who received injections of an investigational vaccine therapy and an approved chemotherapy showed the combination to be well tolerated while also resulting in unexpectedly significant survival increases, researchers at the Duke Cancer Institute report. Patients treated with the study drug (dose-intensified temozolomide and vaccines) were continuously monitored for toxicity and adverse events. Study patients experienced known side effects with temozolomide, including nausea, lymphopenia, thrombocytopenia and fatigue.
There were no treatment limiting a...
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