inflammation tagged posts

How Inflammation causes Gastric Cancer

A schematic illustration of the role of Noxo1 and NOX1 in the inflammation-associated gastric tumorigenesis. Helicobacter pylori infection causes chronic gastritis, which further induces expression of Noxo1 through TNF-α/NF-κB inflammatory cytokine pathway. Induction of Noxo1 as well as other NOX1 complex, such as NOX1, Noxa1 and Cyba, leads to activation of NOX1 complex and ROS production. Increased ROS level in the inflamed gastric mucosa results in expansion of SOX2-positive stem cell population, which induces gastritis-associated gastric metaplasia and hyperplasia. This Noxo1-involved inflammatory pathway contributes to gastric tumorigenesis in the H. pylori-infected stomach.
CREDIT
Kanazawa University

Researchers have solved the decades-old mystery of how stomach bacterium He...

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Colon Cancer Growth reduced by Exercise

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Could short bursts of high-intensity exercise immediately reduce the growth of colorectal cancer cells?

Exercise may play a role in reducing the growth of colon cancer cells according to new research published in The Journal of Physiology. The study found that after a short session of high intensity interval training (HIIT), growth of colon cancer cells was reduced, and this also increased indicators of inflammation.

For a long time, the focus on exercise has been on the positive changes in the body that occur following a longer period of training. However, these findings suggest that the effects following a single session of HIIT, an exercise regime involving short, high energy bursts are also important...

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Antibody Blocks Inflammation, protects mice from Hardened Arteries and Liver disease

The aorta of a mouse model of atherosclerosis on a high-fat diet for 12 months (top) has significantly more plaques (bright red) than the aorta of the same type of mouse that also produces the anti-inflammatory E06 antibody (bottom). Credit: UC San Diego Health

The aorta of a mouse model of atherosclerosis on a high-fat diet for 12 months (top) has significantly more plaques (bright red) than the aorta of the same type of mouse that also produces the anti-inflammatory E06 antibody (bottom). Credit: UC San Diego Health

Researchers at University of California San Diego School of Medicine discovered that they can block inflammation in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardening of the arteries and liver disease, and prolonged their lives.

This study, published June 6 by Nature, marks the first demonstration in a living system that OxPL triggers in...

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How to Engineer a Stronger Immune System

Josh Zimmerman, Ph.D., (right) and Todd McDevitt, Ph.D., discovered a biomaterials hack that can boost cells' ability to combat inflammation and potentially treat autoimmune diseases. Credit: Elisabeth Fall

Josh Zimmerman, Ph.D., (right) and Todd McDevitt, Ph.D., discovered a biomaterials hack that can boost cells’ ability to combat inflammation and potentially treat autoimmune diseases. Credit: Elisabeth Fall

A biomaterials hack can boost cells’ ability to combat inflammation and potentially treat autoimmune diseases. With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders. Their work could one day benefit patients who suffer from IBD or organ transplant rejection.

Mesenchymal stromal cells (MSCs) reside in bone marrow and have been found to secrete anti-inflammatory proteins that help regulate the immune system...

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