Two recent studies from the University of California, Riverside, published in the same issue of Gut Microbes highlight the role of a gene called PTPN2 in protecting the gut from harmful bacteria linked to inflammatory bowel disease (IBD).
Led by Declan McCole, a professor of biomedical sciences in the School of Medicine, the studies show that when PTPN2 does not function properly, the gut becomes more vulnerable to infection and inflammation.
People with IBD often have higher levels of AIEC, a harmful type of E. coli bacteria. AIEC can attach to the gut lining, invade gut cells, damage the gut’s protective barrier, and worsen inflammation.
Normally, PTPN2 helps maintain gut health by controlling inflammation and supporting a balanced gut microbiome...
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