inflammatory disorders tagged posts

Disarming a Blood-Clotting Protein Prevents Gum Disease in mice

Compared to healthy volunteers (left), gum tissue from people with severe periodontal disease (right) shows high levels of fibrin (magenta). Lakmali Silva, NIDCR

Human and animal study offers insight into treating periodontal disease and other inflammatory disorders. Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health. Drawing on animal and human data, the researchers found that buildup of the protein, called fibrin, triggers an overactive immune response that damages the gums and underlying bone...

Read More

Specific Fatty Acids may Worsen Crohn’s Disease

A new software tool allows scientists to link different human diseases and traits through the genetic variations they share. Credit: Liuyang Wang, Dennis Ko lab

A new software tool allows scientists to link different human diseases and traits through the genetic variations they share. Credit: Liuyang Wang, Dennis Ko lab

A new study hints we should be paying attention to omega-6, omega-7 for improving/ worsening Crohn’s. Some research has suggested that omega-3 fatty acids can relieve inflammation. Research has suggested high-fat diets may be linked with Crohn’s disease, but never have the 2 been joined through shared genetics. Certain subtle genetic variations — as small as a single-letter change in the DNA — seem to occur more often in people with Crohn’s disease. Separate lines of work show that specific genetic variations are linked to higher levels of some fatty acids (molecular building blocks of fat) in the bloodstream.

In the new study, res...

Read More