insulin resistance tagged posts

Uncovered: Key to how Exercise Protects against Consequences of Ageing

Staining showing mitochondria within individual muscle fibres. Credit: Monash University

Monash University, Australia scientists have discovered an enzyme that is key to why exercise improves our health. Importantly this discovery has opened up the possibility of drugs to promote this enzyme’s activity, protecting against the consequences of aging on metabolic health, including type 2 diabetes.

The proportion of people worldwide over 60 years old will double in the next three decades and by 2031, more than six million Australians will be over 65 years old. The incidence of type 2 diabetes increases with age so this aging population will also result in an increased incidence of the disease globally.

One of the main reasons for the increased prevalence of type 2 diabetes with age i...

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High-Fat Diet and Gut Bacteria Linked to Insulin Resistance

Gut-associated IgA immune cells regulate obesity-related insulin resistance. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11370-y

Researchers have discovered how our choice of diet can weaken our gut immune system and lead to the development of diabetes. A growing body of research supports that during obesity, our immune system is often responding to components of bacteria that “leak” through the intestinal tissue and results in inflammation. In turn, inflammation can drive insulin resistance, which predisposes people to diabetes.

In new research published in Nature Communications this week, Dr...

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Does Insulin Resistance cause Fibromyalgia?


Effect of metformin treatment on pain as measured by the NPRS (0–10 scale).

A newly confirmed link with insulin resistance may radically change the way fibromyalgia and related forms of chronic pain are identified and managed. Researchers led by a team from The University of Texas Medical Branch at Galveston were able to dramatically reduce the pain of fibromyalgia patients with medication that targeted insulin resistance.

This discovery could dramatically alter the way that chronic pain can be identified and managed. Dr. Miguel Pappolla, UTMB professor of neurology, said that although the discovery is very preliminary, it may lead to a revolutionary shift on how fibromyalgia and related forms of chronic pain are treated...

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Light Exposure during Sleep may Increase Insulin Resistance

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Chronic overnight light exposure could have long-term effects on metabolic function. According to preliminary results from a new study, nighttime light exposure during sleep may affect metabolic function. The aim of this study was to test the hypothesis that light exposure at night during sleep adversely impacts metabolic outcomes.
 
“Our preliminary findings show that a single night of light exposure during sleep acutely impacts measures of insulin resistance,” said lead author Ivy Cheung Mason, PhD, who was a postdoctoral fellow at Northwestern University Feinberg School of Medicine when this study was conducted. “Light exposure overnight during sleep has been shown to disrupt sleep, but these data indicate that it may also have the potential to influence metabolism.”
 
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