insulin resistance tagged posts

Intrahepatic IFN-I signaling and responsive CD8+ T cells promote metabolic disease in mice and correlate to worsened NAFLD in humans.

A high-fat diet and obesity turn “hero” virus-fighting liver immune cells “rogue”, leading to insulin resistance, a condition that often results in type 2 diabetes, according to research published today in Science Immunology. Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8+ T cells, white blood cells in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease-driving cells.

Scientists have been trying for many years to discover why the liver continues to pump out too ...

This image shows the impact of saturated fatty acids on the liver, muscles and fatty tissue. Credit: © DDZ

The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists at the German Diabetes Center and the Helmholtz Center in Munich (HMGU) have found that even the one-off consumption of a greater amount of palm oil reduces the body’s sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver. The results of the study provide information on the earliest changes in the metabolism of the liver that in the long term lead to fatty liver disease in overweight persons as well as in those with type 2 diabetes.

DZD researchers working at the Germa...

2-hour moderate-intensity exercise in the exercise trial; Early PP, early postprandial period; Late PP, late postprandial period.

The researchers also found timing of exercise may play a role in how beneficial it is for your metabolism. The study’s senior author, Katarina Borer, said the study illustrates that small changes can make a difference, such as watching the kinds of foods you eat and not exercising at an inappropriate time. The study reported that when people ate 3 meals containing just 30% carbohydrates over a 24-hour period, they had a 30% reduction in their after-meal insulin resistance and insulin levels. People who are resistant to insulin have a higher risk of prediabetes and type 2 diabetes.

When people ate 3 meals containing 60% carbohydrates over 24 hours, there was no s...

Too much fat in the diet promotes insulin resistance by spurring chronic inflammation. In the image above, immune cells (shown in green) produce fatty acids that contribute to diabetes-related inflammation. Researchers at Washington University School of Medicine have developed a way to block production of fatty acids in these immune cells in mice and protect them from diet-induced diabetes. Credit: Semenkovich lab/ Washington University

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers at Washington University School of Medicine in St. Louis have identified a possible trigger of chronic inflammation...