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    interferon-beta tagged posts

    Immune Gene Prevents Parkinson’s disease, Dementia

    October 9, 2015, Categories  Biology/Biotechnology, Health/Medical

    Highlights •Lack of neuronal IFN-β-IFNAR signaling causes brain Lewy body accumulation •IFN-β deficiency causes late-stage autophagy block and thereby α-synuclein aggregation •IFN-β promotes neuronal autophagy and α-synuclein clearance •Ifnb gene therapy prevents dopaminergic neuron loss in a familial PD model

    Highlights •Lack of neuronal IFN-β-IFNAR signaling causes brain Lewy body accumulation •IFN-β deficiency causes late-stage autophagy block and thereby α-synuclein aggregation •IFN-β promotes neuronal autophagy and α-synuclein clearance •Ifnb gene therapy prevents dopaminergic neuron loss in a familial PD model

    Non-inheritable PD may be caused by functional changes in the immune regulating gene Interferon-beta. Treatment with Interferon-beta-gene therapy successfully prevented neuronal death and disease effects in an experimental model of PD.

    7-10 million people worldwide are living with PD. More than half of PD patients develop progressive disease showing signs of dementia similar to Alzheimer’s disease...

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