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    Cancer researchers identify the ‘switch’ that allows intestinal cells to regenerate after injury

    March 26, 2025, Categories  Biology/Biotechnology, Health/Medical

    Cancer researchers identify the 'switch' that allows intestinal cells to regenerate after injury
    Suppressing H3K36 methylation induces the accumulation of abnormal secretory cells. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-024-01580-y

    Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

    Peter Dempsey, Ph.D., professor of pediatrics–developmental biology in the CU School of Medicine, and Justin Brumbaugh, Ph.D., assistant professor of molecular, cellular, and developmental biology at CU Boulder, recently published a paper in the journal Nature Cell Biology showing the importance of the H3K36 methylation process in regulating plasticity and regeneration in intestinal cells.

    “The intestine has an enormous ability to regenerate itself after injury, an...

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