intestinal nutrient sensors tagged posts

Gut Instincts: Intestinal Nutrient Sensors

A human intestinal organoid, displaying typical ‘budding crypts’ and a central ‘villus-like’ domain. The main intestinal cell types are shown in green, blue, red and purple. Membranes are yellow and nuclei cyan. Credit: Ninouk Akkerman, Yannik Bollen and Jannika Finger, Institute of Human Biology

A multi-institutional group of researchers led by the Hubrecht Institute and Roche’s Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion. In response to incoming food, these hormones are secreted by rare hormone producing cells in the gut and play key roles in managing digestion and appetite. The team has developed new tools to identify potential ‘nutrient sensors’ on these hormone producing cells and study their function...

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