inulin tagged posts

Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell Medicine investigators. The surprising findings could pave the way for therapeutic diets that may help ease symptoms and promote gut health.

The study, published March 20 in the Journal of Experimental Medicine, shows that inulin, which is found in foods such as garlic, leeks and sunchoke, as well as commonly used fiber supplements and foods with added fiber, stimulates microbes in the gut to release bile acids that increase the...

Many people don’t realize that the trillions of bacteria, viruses, and fungi residing within the gastrointestinal tract — collectively called the gut microbiome — are connected to overall health, and specifically to cancer.

Manipulating the gut microbiome to produce “beneficial” commensal microbes, which protect the host from pathogens and can boost immune responses, among other things, could potentially help patients respond better to cancer drugs called immune checkpoint inhibitors, a type of immunotherapy.

To that end, researchers at the University of Michigan have developed a new dietary fiber formulation that improves the potency of immunotherapies against cancer by modulating the gut microbiome...

A visualization of the changes to the colon and the gut bacteria after eating a low-fiber, Western-type diet and then subsequently eating a diet supplemented with fiber. Credit: Shroeder, et al.

Anyone watching their waistline this holiday season may want to pay attention to what their gut bacteria are eating. It’s not just calories that matter in a healthy diet – it’s fiber that resists digestion by the body but is readily eaten by bacteria in the gut. The amount of fiber in someone’s diet can influence weight gain, blood sugar, insulin sensitivity, and colon health. Two studies with mice, publishing December 21 in the journal Cell Host & Microbe, help shed light on how and why fiber has such a powerful effect on the entire body.

“Once the mechanism is understood, it can be exploited in d...

A new study highlights the importance of the gut microbiome in maintaining intestinal and metabolic health and suggests that eating more foods high in soluble fiber may help prevent metabolic disease and obesity.

Eating too much high-fat, high-calorie food is considered the primary cause of obesity and obesity-related disease, including diabetes. While the excess calories consumed are a direct cause of the fat accumulation, scientists suspect that low-grade inflammation due to an altered gut microbiome may also be involved. A new study finds in mice that a diet missing soluble fiber promotes inflammation in the intestines and poor gut health, leading to weight gain. Moreover, incorporating soluble fiber back into the diet can restore gut health.

Georgia State University team examined...