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    inverse relationship between methylation drift and longevity tagged posts

    Mechanism Behind Calorie Restriction, Lengthened Lifespan Revealed

    September 14, 2017, Categories  Biology/Biotechnology, Health/Medical

    DREAM analysis in CR animals. a Unsupervised hierarchical clustering analysis of methylation values in all genomic regions. The green to red scale indicates the methylation percentage. The color codes for age and caloric status are shown on the left. b DNA methylation in AL old animals vs. CR old animals. Average DNA methylation level of each CpG site in CR old individuals (x axis), methylation in AL old individuals is shown on the y axis. The red and green dots represent CpG sites within CGI and non-CGI, respectively. The full range (0–100%) of methylation level is shown on the left and the low range (0–20%) is magnified and shown on the right. c Correlation between the effects of CR and age-related methylation drift in AL animals. The x axis shows methylation changes per year in AL-fed animals. Positive/negative value means methylation increase/decrease with age, respectively. The y axis shows the differences of methylation percentage between CR old and AL old animals. Each dot represents a CpG site. Spearman r values and the corresponding two-tailed p-values were calculated

    DREAM analysis in CR animals. a Unsupervised hierarchical clustering analysis of methylation values in all genomic regions. The green to red scale indicates the methylation percentage. The color codes for age and caloric status are shown on the left. b DNA methylation in AL old animals vs. CR old animals. Average DNA methylation level of each CpG site in CR old individuals (x axis), methylation in AL old individuals is shown on the y axis. The red and green dots represent CpG sites within CGI and non-CGI, respectively. The full range (0–100%) of methylation level is shown on the left and the low range (0–20%) is magnified and shown on the right. c Correlation between the effects of CR and age-related methylation drift in AL animals...

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