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    IRE-1 tagged posts

    In Cells, Some Oxidants are needed

    August 19, 2016, Categories  Biology/Biotechnology, Health/Medical

    Highlights •The ER stress sensor IRE-1 has a distinct function in cytoplasmic homeostasis •Local redox signals block IRE-1 ER signaling by sulfenylating a kinase cysteine •This functional switch initiates the p38/SKN-1(Nrf2) antioxidant response at IRE-1 •The IRE-1 paradigm implies broad and versatile functions for signaling at cysteines

    Highlights •The ER stress sensor IRE-1 has a distinct function in cytoplasmic homeostasis •Local redox signals block IRE-1 ER signaling by sulfenylating a kinase cysteine •This functional switch initiates the p38/SKN-1(Nrf2) antioxidant response at IRE-1 •The IRE-1 paradigm implies broad and versatile functions for signaling at cysteines

    Reactive oxygen species (ROS) sometimes can aid in maintaining health – findings now boosted by a surprising discovery from the researchers. In other circumstances, high levels of reactive forms of oxygen can damage proteins and contribute to diabetic complications and many other diseases.

    Led by Keith Blackwell, M.D., Ph.D...

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