JAK-STAT signaling pathway tagged posts

Nutrients drive Cellular Reprogramming in the Intestine

A detailed summary of this study: the Drosophila adult midgut rapidly grows in size upon the first food intake after eclosion or upon refeeding after starvation. ©Hiroki Nagai et al.

Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation — where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells.

Until now, dedifferentiation has primarily been associated with severe injuries or stressful conditions, observed during tissue regeneration and diseases like tumorigenesis...

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