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    KCC2 tagged posts

    Paralyzed Mice with Spinal Cord Injury made to Walk Again

    July 22, 2018, Categories  Biology/Biotechnology, Health/Medical

    A cross section of a mouse spinal cord, stained two different ways, showing increased expression of KCC2 in inhibitory neurons. This increased expression correlated with improved motor function, including ankle movement and stepping. Credit: Zhigang He Lab, Boston Children's Hospital

    A cross section of a mouse spinal cord, stained two different ways, showing increased expression of KCC2 in inhibitory neurons. This increased expression correlated with improved motor function, including ankle movement and stepping. Credit: Zhigang He Lab, Boston Children’s Hospital

    Small-molecule drug reactivates dormant nerve pathways; could complement regenerative strategies. Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn’t completely severed. Why don’t the spared portions of the spinal cord keep working? Researchers at Boston Children’s Hospital now provide insight into why these nerve pathways remain quiet...

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    Discovery of a New Drug Target could lead to Novel Rx for Severe Autism

    January 4, 2016, Categories  Biology/Biotechnology, Health/Medical

    In this composite image, a human nerve cell derived from a patient with Rett syndrome shows significantly decreased levels of KCC2 compared to a control cell. Image: Gong Chen lab, Penn State University


    In this composite image, a human nerve cell derived from a patient with Rett syndrome shows significantly decreased levels of KCC2 compared to a control cell.
    Image: Gong Chen lab, Penn State University

    Penn State University scientists have discovered a novel drug target and have rescued functional deficits in human nerve cells derived from patients with Rett Syndrome, a severe form of autism-spectrum disorder. It could lead to a new treatment for Rett Syndrome and other forms of autism-spectrum disorders, ASD.

    “The most exciting part of this research is that it directly uses human neurons that originated from Rett Syndrome patients as a clinically-relevant disease model to investigate the underlying mechanism,” said Dr. Chen...

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