Kinesin-14 promotes DSB mobility.
It’s a discovery that could unlock secrets into how cancer operates. “Scientists knew that severely injured DNA was taken to specialized ‘hospitals’ in the cell to be repaired, but the big mystery was how it got there,” said Professor Karim Mekhail, He discovered this DNA ambulance, which is a kinesin-14 motor protein complex, by using yeast cells.
Mekhail’s team also found that the DNA hospital, ie nuclear pore complex, repairs damaged DNA inaccurately. This inaccurate fix is important because DNA contains the instructions for all our genetic information. While the repaired DNA can still replicate, it has irregular cell instructions – a scenario that could cause cancer.
Daniel Durocher, Senior Investigator at Mount Sinai’s Lunenfeld-Tanenbaum Research I...
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