Do more with one link - claim and personalize your FREE link today! Effortlessly schedule, video meet, message chat, network, share materials, e-sign, etc – all in one spot. Collaborate, Nurture connections, Improve client services, Expedite deal closures, and more. 💼 Join FREE!!

Recent Comments

    L-DOPA tagged posts

    Study finds Dopamine Regulates How Quickly and Accurately Decisions are made

    September 23, 2023, Categories  Biology/Biotechnology, Health/Medical

    Dopamine regulates how quickly and accurately decisions are made
    Behavioral data. Response time (RT) distributions (n = 31, within-subject design) under Placebo (a), L-dopa (b), and Haloperidol (c). Choices of the suboptimal (20% reinforced) options in (a–c) are coded as negative RTs, whereas choices of the optimal (80% reinforced) options are coded as positive RTs. d Accuracy per drug condition (chance level is 0.5). e Total rewards earned per condition. f Median RT per drug condition. Pl – Placebo, L – L-dopa, H – Haloperidol. For boxplots, lines represent the median, the box covers the upper and lower quartiles, and the whiskers denote the range of datapoints falling within 1.5 times the interquartile range. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-41130-y

    A recent study provides new insight into the relat...

    Read More

    New Study puts Gut Microbiome at the Center of Parkinson’s Disease Pathogenesis

    January 11, 2023, Categories  Biology/Biotechnology, Health/Medical

    Fig. 2
     PD-associated species nominated by consensus of MaAsLin2 and ANCOM-BC. Analysis included N = 724 biologically independent samples from 490 PD and 234 neurologically healthy control (NHC) subjects. a 257 species (denoted by circles in the plot) were tested in microbiome-wide association study (MWAS) with two statistical methods: MaAsLin2 and ANCOM-BC. The results are shown according to significance (−log10 of the FDR) achieved by MaAslin2 (Y-axis) vs ANCOM-BC (X-axis). Corresponding untransformed FDR values are provided in parentheses on the X and Y axes for easier interpretation. 84 species were nominated as PD-associated, defined by FDR < 0.05 by one method and FDR≤0.1 by the other: 68 achieved FDR < 0.05 by both methods, 10 achieved ANCOM-BC MaAsLin2 FDR < 0.05 by MaAsLin2 and FDR≤0...
    Read More

    Tomatoes offer Affordable Source of Parkinson’s disease Drug

    December 11, 2020, Categories  Biology/Biotechnology, Health/Medical

    Metabolic engineering of tomato fruit enriched in L-DOPA
    Author links open overlay panelDarioBreitelacPaulBrettaSalehAlseekhbAlisdair R.FerniebEugenioButelliaCathieMartina

    Scientists have produced a tomato enriched in the Parkinson’s disease drug L-DOPA in what could become a new, affordable source of one of the world’s essential medicines.

    The development of the genetically modified (GM) tomato has implications for developing nations where access to pharmaceutical drugs is restricted.

    This novel use of tomato plants as a natural source of L-DOPA also offers benefits for people who suffer adverse effects — including nausea and behavioral complications — of chemically synthesised L-DOPA .

    Tomato — was chosen as a widely cultivated crop that can be used for scaled up production a...

    Read More