Highlights •IFN-γ and 4D5 act directly on erbB2-positive breast cancer cells •IFN-γ, but not IFN-α or β, cooperates with 4D5 directly on erbB2+ breast cancer cells •IFN-γ and 4D5 alters KLF4 levels and degrades Snail by the GSK3-β/proteasome pathway •Sequential combination treatment with mAb and IFN-γ sensitizes for tumor eradication. Credit: http://dx.doi.org/10.1016/j.celrep.2015.08.044
This therapy, when translated for use in people humans, would be beneficial in reducing toxicity because the amount of antibody could be decreased by 2/3 and the amount of chemotherapy by at least 1/2, they say. This in turn, “reduces the cost of treatment so that individuals previously not able to afford targeted therapy will be able to do so.
“This line of research is important to future ...
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