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This figure shows that the healthy participants who received prucalopride had greater functional connectivity between key cognitive regions (the posterior / anterior cingulate cortices) and a major cognitive network (the central executive network). That is, they appeared to be strengthening their connectivity within cognitive networks (Credit: de Cates, et al., Biological Psychiatry: Cognitive Neuroscience and Neuroimaging).
Cognitive deficits accompany mood disorders and other psychiatric conditions, often with debilitating effects. Limited treatments currently exist, but studies in animals and humans have pointed to drugs such as the laxative prucalopride that activate serotonin receptors as a potential therapeutic for the symptoms...
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