Neural stem cells (green) migrate throughout an injured brain site in DLB mice and begin to differentiate into astrocytes (red), leading to improved motor and cognitive function. Blurton-Jones lab
DLB is the 2nd-most common type of age-related dementia after Alzheimer’s disease and is characterized by the accumulation of a protein alpha-synuclein that collects into spherical Lewy bodies – which also accumulate in related disorders, including Parkinson’s disease. This pathology, in turn, impairs the normal function of neurons, leading to alterations in critical brain chemicals and neuronal communication and, eventually, to cell death.
One day transplantation of neural stem cells into human patients might help overcome the motor and cognitive impairments of DLB...
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