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    Lithium loss ignites Alzheimer’s, but lithium compound can reverse disease in mice

    August 8, 2025, Categories  Biology/Biotechnology, Health/Medical

    One pair of boxes shows fewer green amyloid clusters on the left and more on the right. Another pair of boxes shows a dim arc of purple and red tau on the left and a brighter arc on the right.
    Top row: In a mouse model of Alzheimer’s disease, lithium deficiency (right) dramatically increased amyloid beta deposits in the brain compared with mice that had normal physiological levels of lithium (left). Bottom row: The same was true for the Alzheimer’s neurofibrillary tangle protein tau. Images: Yankner Lab

    What is the earliest spark that ignites the memory-robbing march of Alzheimer’s disease? Why do some people with Alzheimer’s-like changes in the brain never go on to develop dementia? These questions have bedeviled neuroscientists for decades.

    Now, a team of researchers at Harvard Medical School may have found an answer: lithium deficiency in the brain.

    The work, published in Nature, shows for the first time that lithium occurs naturally in the brain, shields it from ...

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