liver disease tagged posts

•SQSTM1/p62 is ubiquitylated by TRIM21 at K7 via K63-linkage •p62 K7 ubiquitylation prevents its dimerization and sequestration •TRIM21 negatively regulates Keap1 sequestration and anti-oxidative response •TRIM21 null liver and heart are protected from oxidative tissue damage

Protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was found not work efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humans. This caused oxidative stress and allowed the release of harmful molecules, called free radicals, which resulted in serious illness. One of the body’s first lines of defense, the cells antioxidant response system is supposed to prevent these harmful invaders from causing a domino effect and damaging other cells.

A natural compound, limonene, found in oranges and lemons, could be indicative in early-stage diagnosis of liver disease. Patients with this illness do not often present with symptoms until the disease is advanced. Even then diagnosis is difficult and the symptoms and signs are often general and can be mistaken for other pathologies. For advanced cirrhosis liver,transplant is the only treatment.

In the UK liver disease has risen sharply over the past few decades and is the 3rd biggest cause of premature mortality, with 3/4 of liver deaths due to alcohol. Patients do not often present with symptoms until the disease is advanced.

The R enantiomer of limonene smells like oranges. The S enantiomer smells like lemons. Credit: https://jahschem.wikispaces.com/stereochem+in+biology

The Molec...