Liver-specific Dpp4 overexpression tagged posts

NAFLD patients have augmented plasma DPP4 activity.
•Hepatocyte-specific DPP4 overexpression in mice.
(1) promotes fatty liver disease.
(2) induces hepatic insulin resistance.
(3) reduces systemic levels of active GLP-1.
(4) enhances adipose tissue expansion and inflammation.

In mice given a high-fat diet, an increased production of the enzyme DPP4* by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance. These were the findings of a current study by DZD-researchers in Potsdam and Tübingen...