long noncoding RNA tagged posts

New Strategy against Treatment-Resistant Prostate Cancer identified

A study from Washington University School of Medicine in St. Louis has identified an RNA molecule that suppresses prostate tumors. According to the research — conducted in mice implanted with human prostate tumor samples — restoring this so-called long noncoding RNA could be a new strategy to treat prostate cancer that has developed resistance to hormonal therapies. Pictured are prostate cancer cells. The androgen receptor is shown in dark red. Cell nuclei are outlined in blue. MAHAJAN LAB

A new study has identified an RNA molecule that suppresses prostate tumors. The scientists found that prostate cancers develop ways to shut down this RNA molecule to allow themselves to grow...

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First immune stimulating long noncoding RNA involved in body’s response to cancer

cancer cell in orange under microscope
Illustration of a T cell attacking a cancer cell. Roger Harris/Science Photo Library via Getty Images.

A long noncoding RNA whose function was previously unknown turns out to play an important role in promoting the body’s immune response against cancer and holds promise for enhancing the efficacy of anti-cancer immunotherapy.

That’s according to new findings reported in Nature Cell Biology by researchers at the University of Michigan Rogel Cancer Center.

The group dubbed the RNA they identified LIMIT—for long noncoding RNA inducing major histocompatibility complex class I and immunogenicity of tumor.

“LIMIT is easy to remember, but really it does the opposite. It stimulates immune functions against cancer,” says senior study author Weiping Zou, M.D., Ph.D., the Charles B...

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