long-term memory of the immune system tagged posts

mRNA-based COVID-19 vaccines train the ‘long-term memory’ of the immune system, study reveals

mRNA-based COVID-19 vaccines train the 'long-term memory' of the immune system
Cytokine release in macrophages following SARS-CoV-2 mRNA vaccination. Credit: Molecular Systems Biology (2025). DOI: 10.1038/s44320-025-00093-6

Researchers at the University of Cologne and University Hospital Cologne have determined that the novel mRNA-based COVID-19 vaccines not only induce acquired immune responses such as antibody production, but also cause persistent epigenetic changes in innate immune cells.

The study, “Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages,” led by Professor Dr. Jan Rybniker, who heads the Division of Infectious Diseases at University Hospital Cologne and is a principal investigator at the Center for Molecular Medicine Cologne (CMMC), and Dr...

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