loss of health and function tagged posts

Senolytic Drugs Reverse Damage caused by Senescent Cells in Mice

D + Q reduces senescent cell abundance and decreases proinflammatory cytokine secretion in human adipose tissue.

D + Q reduces senescent cell abundance and decreases proinflammatory cytokine secretion in human adipose tissue.

Injecting senescent cells into young mice results in a loss of health and function but treating the mice with a combination of two existing drugs cleared the senescent cells from tissues and restored physical function. The drugs also extended both life span and health span in naturally aging mice, according to a new study in Nature Medicine, published on July 9, 2018.
A research team led by James L. Kirkland, M.D., Ph.D., of the Mayo Clinic in Rochester, Minnesota, found that injecting even a small number of senescent cells into young, healthy mice causes damage that can result in physical dysfunction...
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