lung cancer tagged posts

Researchers found that inhibiting protein BMI1 was able to impair tumour growth in lung cancer. The study was led by Professor Daniel Tenen, Director of CSI Singapore et al. Lung cancer is one of the deadliest cancers in the world, accounting for 30% of tumour-related deaths. Like many solid tumours, lung cancer is very heterogeneous (consisting of cancer cells which behave and respond differently) and hence there is currently no single efficient drug which is able to treat all patients.

Prof Tenen has worked on the differentiation factor C/ EBPa for several decades, demonstrating that it is an important tumour suppressor, first in acute myelogenous leukemia, and subsequently, in studies in collaboration with Dr Levantini, in lung cancer...

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In a new analysis, researchers have shed light on these hereditary elements across 12 cancer types – showing a surprising inherited component to stomach cancer and providing some needed clarity on the consequences of certain types of mutations in well-known breast cancer susceptibility genes, BRCA1 and BRCA2...

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The results reinforce previous findings that antioxidants hasten the progression of lung cancer. People with cancer or an elevated risk of developing the disease should avoid nutritional supplements that contain antioxidants, the researchers say. Given well-established evidence that free radicals can cause cancer, the research community had simply assumed that antioxidants, which destroy them, provide protection against the disease.

“As opposed to the lung cancer studies, the primary melanoma tumor was not affected,” Professor Bergö says. “But the antioxidant boosted the ability of the tumor cells to metastasize, an even more serious problem because metastasis is the cause of death in the case of melanoma. The primary tumor is not dangerous per se and is usually removed.”

Experiments ...

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Panel of 5 serum microRNAs could lead to accurate, early diagnosis of NSCLC in ethnically diverse patients

Early-stage Non-small-cell Lung Cancer is asymptomatic and difficult to detect since no blood test for NSCLC is currently available. In a new study, researchers identified a panel of five serum microRNAs as the potential biomarker for NSCLC diagnosis.

MiRNAs are a family of small, single-stranded non-coding RNAs that are critical regulators of numerous diseases, and their expression patterns have the potential to diagnose various types of cancer. This is the first multiethnic, multicentric, single-blind global analysis of miRNA expression patterns of NSCLC patients in four independent cohorts from five centers in both China and America...

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