lymphoma tagged posts

Inhibition of Mdm2–MdmX RING–RING interaction by MMRi6 and its analog MMRi64.

A new class of small-molecule compounds has been discovered that are good candidates for novel targeted therapies in leukemia and lymphoma Rx. They drive cancer cells to suicide, RPCI researchers report. “We are excited about the unique activities of these compounds and will continue to focus our research efforts on development of their clinical potential,” says Xinjiang Wang, PhD. “These compounds kill cancer cells, not just stop cancer cell growth temporarily. These types of agents offer the promise of therapeutic benefit.”

They demonstrated that the small-molecule MMRi compounds have an advantage over p53-activating agents in current use as cancer therapies...

Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumour beyond the lymph node. Credit: Nephron/Wikipedia

Palbociclib, a new oral drug whose efficacy in combating breast cancer has been demonstrated alone and in combination with endocrine therapy, also has potential to combat other types of cancer, according to a literature review and original research at Abramson Cancer Center (ACC) in the University of Pennsylvania.

Palbociclib targets the rapid division of tumor cells by inhibiting the activity of the enzymes CDK4 and CDK6, which propel cell division and increase in number in most cancers. It is the first CDK4/6 inhibitor to be approved for the treatment of breast cancer...