macrophages tagged posts

New study finds that macrophages and macrophage-produced proteins contribute to heartbeat irregularities. Targeting these cells may therefore represent a promising strategy to treat and prevent AFib.

Current treatments for atrial fibrillation (AFib), a common heart condition characterized by fast and irregular beats that can lead to stroke and heart failure, have multiple side effects and are ineffective for preventing AFib recurrence.

New research led by investigators at Massachusetts General Hospital (MGH) and published in Science reveals that certain immune cells play a major role in the development of AFib. Targeting these cells may therefore represent a promising strategy to treat and prevent AFib.

For the work, senior author Matthias Nahrendorf, MD, PhD, an investigator...

Nanoparticle platform delivers a nucleotide that blocks production of scar-promoting protein. Scientists at the University of Illinois Chicago have developed a treatment for pulmonary fibrosis by using nanoparticles coated in mannose — a type of sugar — to stop a population of lung cells called macrophages that contribute to lung tissue scarring. The cell-targeting method holds promise for preventing this severe lung scarring disease, which can result in life-threatening complications like shortness of breath.

The researchers say that the treatment is not yet ready to be tested in clinical trials, but its success in relevant animal models is a promising sign that it may be possible to treat the dise...

Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes. This is shown by a new study carried out by scientists from the University of Bonn together with colleagues from Sao Paulo (Brazil). In the medium term, the results could open up new ways to treat autoimmune diseases. They have now been published in the journal Cell Reports.

For a long time, the role of platelets appeared to be clear: in the event of an injury, they adhere to the wound and stick to each other to rapidly stop the bleeding...

Highlights •Tissue-resident macrophages abound in the mouse and human AV nodes •Connexin 43 connects macrophages with cardiomyocytes •Macrophages modulate the electrical activity of cardiomyocytes •Macrophages assist normal AV nodal conduction

Macrophages have a previously unrecognized role in helping the mammalian heart beat in rhythm. Massachusetts General Hospital researchers discovered that macrophages aggregate around central cardiac cells that regulate electrical impulses within the mouse heart, helping the cells conduct electricity. Mice that were genetically engineered to lack macrophages have irregular heartbeats, hinting that these immune cells may also play a role in heart disease.

“This work opens up a completely new view on electrophysiology; now, we have a new cell ty...