making daily life difficult for millions of people around the world tagged posts

A new genetic link to pain provides a promising drug target

Chronic pain research breakthrough identifies promising drug target
Cryo-EM processing workflow of SLC45A4 in LMNG, including local and global resolution estimates. Credit: Nature (2025). DOI: 10.1038/s41586-025-09326-y

Chronic pain is life-changing and considered one of the leading causes of disability worldwide, making daily life difficult for millions of people around the world, and exacerbating personal and economic burdens. Despite established theories about the molecular mechanisms behind it, scientists have been unable to identify the specific processes in the body responsible, until now.

In an exciting collaboration, a team led by NDCN’s Professor David Bennett, and Professor Simon Newstead in the Department of Biochemistry and Kavli Institute for NanoScience Discovery, have identified a new genetic link to pain, determined the structure o...

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