medial prefrontal cortex tagged posts

Brain Regions that Relieve Effects of Chronic Stress in Mice Differ based on Sex

Schematic of cortical microcircuit showing connections among neurons and how activation of SST neurons leads to stress resilience
New research finds sex-specific regions of the brain can relieve the detrimental effects of chronic stress in male and female mice. Left: Schematic showing a cortical microcircuit with three types of interneurons expressing somatostatin (SST), parvalbumin (PV) or vasointestinal peptide (VIP) and their distinct patterns of innervation of glutamatergic output neurons (PNs), with thin lines representing axons that send chemical signals and the thicker lines of PNs representing dendrites that receive information. There is selective innervation of the distal ends of PN dendrites by axons of SST neurons...
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‘Mindful people’ feel Less Pain; MRI imaging Pinpoints supporting Brain Activity

Greater deactivation of the posterior cingulate cortex, a brain region associated with processing self-related thoughts, was associated with lower pain and higher trait mindfulness.
Credit: Wake Forest Baptist Medical Center

Ever wonder why some people seem to feel less pain than others? A study conducted at Wake Forest School of Medicine may have found one of the answers – mindfulness. “Mindfulness is related to being aware of the present moment without too much emotional reaction or judgment,” said the study’s lead author, Fadel Zeidan, Ph.D., assistant professor of neurobiology and anatomy at the medical school, part of Wake Forest Baptist Medical Center. “We now know that some people are more mindful than others, and those people seemingly feel less pain.”

The study is an article in pre...

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