rs10830963 is an eQTL in human islets conferring increased MTNR1B mRNA expression • Melatonin inhibits cAMP rises in mouse islets and clonal insulin-secreting cells • Melatonin blocks insulin release in mouse islets and clonal insulin-secreting cells • Melatonin’s inhibition of insulin release is stronger in risk allele carriers
A sleeping pancreas releases less insulin, but how much insulin drops each night may differ from person to person. Up to 30% of the population may be predisposed to have a pancreas that’s more sensitive to the insulin-inhibiting effects of melatonin, a circadian rhythm hormone. People with this increased sensitivity carry a slightly altered melatonin receptor gene that is a known risk factor for type 2 diabetes.
Large-scale studies have identified over 100 ...
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