Melatonin tagged posts

Distribution of the 40 nonsynonymous MT2 variants identified by exon resequencing.

New light has been shed on why people who carry a common genetic melatonin receptor mutation may be more at risk for developing type 2 diabetes. By carefully studying healthy subjects, researchers were able to chart the effect of melatonin supplements on blood sugar control. Their results suggest that taking melatonin close to mealtimes may put people with a common genetic variant more at risk.

As many as 50% of people of European ancestry carry this genetic variation in MTNR1B, a gene that encodes a melatonin receptor...

Highlights •Melatonin levels negatively correlate with multiple sclerosis relapses in humans •Melatonin treatment ameliorates pathology in a mouse model of multiple sclerosis •Melatonin blocks ROR-γt expression and Th17 differentiation •Melatonin boosts Tr1 development via Erk1/2 and ROR-α

Researchers have found an explanation that could lead to a deeper understanding of multiple sclerosis and more targeted treatment options for patients. By first looking broadly at possible environmental factors and then deeply at preclinical models of MS, the research team found that melatonin – a hormone involved in regulating a person’s sleep-wake cycle – may influence MS disease activity.

Why do symptoms of multiple sclerosis (MS) seem to get better in the winter and worse in the summer? The...