memory tagged posts

Marijuana appears to hamper blood flow to the brain, which theoretically could affect your memory and ability to reason, a new study suggests.

Marijuana appears to hamper blood flow to the brain, which theoretically could affect your memory and ability to reason, a new study suggests. Brain scans of nearly 1,000 past and present marijuana users revealed abnormally low blood flow throughout their brains, compared with a smaller control group of 92 people who’d never used pot. “The differences were astonishing,” said Dr. Daniel Amen, a psychiatrist and founder of the U.S.-based Amen Clinics. “Virtually every area of the brain we measured was lower in blood flow and activity in the marijuana smokers than in the healthy group.”

Blood flow was lowest in the hippocampus of marijuana users, which...

Aerobic exercise preserves brain volume and improves cognitive function

Using a new MRI technique, researchers found adults with mild cognitive impairment (MCI) who exercised 4 times a week over a 6-month period experienced an increase in brain volume in specific, or local, areas of the brain, but adults who participated in aerobic exercise experienced greater gains than those who just stretched. The study included 35 adults with MCI participating in a randomized, controlled trial of exercise intervention. Individuals with MCI are at risk of developing Alzheimer’s disease (AD) which affects >5 million Americans today.

The participants were divided into two groups...

Brain cells from a mouse cortex that didn’t receive the gene therapy. The amyloid plaques are shown in green, and the glial cells, which surround the plaques, are shown in red (microglia) and magenta (astrocytes). Image 2 shows a mouse cortex that received the gene therapy, and so had fewer amyloid plaques. Credit: Imperial College London

Researchers have prevented development of Alzheimer’s disease in mice by using a modified virus to deliver a specific gene into the brain. The early-stage findings, by scientists from Imperial College London, open avenues for potential new treatments for the disease. Previous studies by the same team suggest this gene, called PGC1 – alpha, may prevent the formation of a protein called amyloid-beta peptide in cells in the lab...

In this study, Drago and Davis show that inhibition of mitochondrial calcium entry in Drosophila mushroom body neurons during development impairs fly memory without altering their capacity to learn. In addition, they show associated defects in the structure and synaptic vesicle content of mushroom body neurons.

TSRI Scientists offer new insights how calcium in mitochondria can impact the development of the brain and adult cognition. In particular, the team showed in fruit flies, a widely used model system, that blocking a channel that brings calcium to the mitochondria, called “mitochondrial calcium uniporter,” causes memory impairment but does not alter learning capacity...